منابع مشابه
Keeping track of AID
966 JEM Vol. 204, No. 5, 2007 A DNA-mutating enzyme that fine-tunes B cell antibody specificity can become a dangerous liability if its activity is mistimed, misplaced, or left unchecked. Crouch et al. (page 1145) have now designed a mouse model to track the enzyme’s activity in B cells during development and immunity. The model can now be used to determine how the enzyme’s destructive force is...
متن کاملKeeping kinetochores on track.
The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in various model organisms. The key challenge sin...
متن کاملKeeping track of individuals
This paper gives attention to a special point in Brandom’s Making it Explicit. Brandom proposes in MIE a “Fregean” way out of Kripke’s puzzle about belief. In the first part, I analyze two main features of Brandom’s strategy, the definition of anaphoric chains as senses of proper names and the implausibility of the application of a disquotational principle to proper names. In the second part, I...
متن کاملKeeping track of worm trackers.
C. elegans is used extensively as a model system in the neurosciences due to its well defined nervous system. However, the seeming simplicity of this nervous system in anatomical structure and neuronal connectivity, at least compared to higher animals, underlies a rich diversity of behaviors. The usefulness of the worm in genome-wide mutagenesis or RNAi screens, where thousands of strains are a...
متن کاملThe Cost of Keeping Track
I show that a lump-sum cost incurred for keeping track of future transactions predicts several known departures from the standard discounting model: an agent who incurs such costs will exhibit decreasing impatience with preference reversals; a magnitude effect, i.e. discounting large amounts less than small amounts; a sign effect, i.e. discounting gains more than losses; and an Andreoni-Sprenge...
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ژورنال
عنوان ژورنال: Serials: The Journal for the Serials Community
سال: 1988
ISSN: 0953-0460
DOI: 10.1629/010230